NutraBio PRE Workout Stimulant Free

    PRE Workout Stimulant Free

    PRESF
    1.90 pounds
    $56.99
    $39.99
     
     



    • Description
    • Supplement Facts
    • Dietary Restrictions
    • Reviews
    • Research Listings
    • Test Results

    PRE Workout Stimulant Free Description

    CAFFEINE FREE PRE-WORKOUT POWERHOUSE

    HOW DOES PRE WORK?

    • Builds explosiveness, power, and strength†
    • Enhances endurance and increases reps†
    • Accelerates performance and recovery†
    • Supercharges mental focus and acuity†
    • No proprietary blends and full label disclosure.
    • 6.5GLeucine & Creatine
    • 2.5G Beta-Alanine

    NutraBio PRE Stim-Free, as the name implies, is our stimulant free version of our PRE formula. We created PRE Stim-Free for those individuals who are sensitive to ingredients such as caffeine, hit the gym late at night, or otherwise want a pre-workout with the performance boosting ingredients found in PRE minus the stimulants. To that extent we can say PRE Stim-Free is absolutely the most thorough, effective, and purest stimulant free pre-workout in existence. PRE Stim-Free is built upon clinically dosed and scientifically backed ingredients proven to maximize workout performance and produce results. Athletes of all levels realize that in order to achieve the most effective training session that strength, endurance, energy production, and focus are a must. A complete stimulant free pre-workout supplement should support all of these benefits. The synergistic combination of ingredients found in PRE Stim-Free help prepare your body physiologically and psychologically by supporting increases in muscular strength, power, and endurance, enhancing the mind-muscle connection, and combatting fatigue.  From top to bottom PRE Stim-Free will help keep you training stronger and longer. Take a deeper look into PRE Stim-Free and you will find:

    • Clinical doses of 15 research-backed ingredients
    • Carnosyn Beta-Alanine to increase endurance and help counteract fatigue caused by hydrogen ion accumulation.
    • Pharmapure creatine monohydrate for greater strength, power, and muscle growth. Creatine MagnaPower for increased solubility and absorption.
    • L-Leucine to help stimulate muscle protein synthesis, prevent muscle catabolism, and lessen recovery time between sessions.
    • Huperzine A to promote a strong mind-muscle connection and supercharge mental focus.
    • Betaine anhydrous to support creatine production, increase power and strength output, and protect cells from dehydration.
    • Agmatine sulfate and Nitrosigine to stimulate nitric oxide pathways leading to greater vasodilation and bigger muscle pumps.
    • Electrolyte and hydration optimizer that helps maintain water balance in the muscle, facilitates motor neuron function, and increase exercise capacity.

    Since day one NutraBio has never been happy maintaining the status quo when it comes to pre-workouts. We have always been the innovators; not the replicators. Although the industry makes it seems like non-proprietary blends, proper dosing, and scientifically backed ingredients are something new; the fact is NutraBio pioneered this trend over 15 years ago.  We focused on creating the best, and we've done just that with PRE Stim-Free. PRE Stim-Free has everything you need in one comprehensive, open label, clinically dosed formula and nothing you don't. We pride ourselves on purity. What you see on the label is exactly what you get. PRE Stim-Free contains no fillers, excipients, proprietary blends, or other potentially unhealthy or unneeded additives.
    At the end of the day, NutraBio isn't just about marketing hype and trying to maximize our profit. It's all about giving athletes what they want to meet their performance needs by giving them access to clean supplements that are innovative and effective. Like you, we want to train hard and see the results of our efforts.  Compare NutraBio PRE Stim-Free to any other stimulant free pre-workout on the market and ask yourself whose formula was created WITHOUT COMPROMISE. We think you'll find that even the most "self-proclaimed" strongest formulated stimulant free pre-workouts pale in comparison to PRE Stim-Free.
    Game over. NutraBio PRE Stim-Free dominates the stimulant free pre-workout landscape.

    The Science Behind NutraBio PRE Stim-Free

    A closer look at the 15 ingredients and doses used to make NutraBio PRE Stim-Free the premier stimulant free pre-workout on the market.

    POWER, STRENGTH & ENDURANCE COMPLEX

    L-LEUCINE

    • Leucine is one of the essential branched chain amino acids (BCAA). By itself it can stimulate muscle protein synthesis; the process responsible for muscle growth and recovery.  This is why it is often referred to as the "main" amino acid.
    • Supplementation with at least 2/grams daily leucine has been shown decrease muscle soreness, lessen recovery time between workouts, and increase lean muscle mass.
    • Howatson et al. (2012) discovered that leucine (combined with isoleucine and valine) administered before muscle damaging resistance exercises reduced indices of muscle damage and accelerated recovery in resistance trained males.
    • NutraBio's leucine is derived from fermented vegetables sources as opposed to animal based sources.

    BETA ALANINE (AS CARNOSYN)

    • Beta-alanine (BA) is a version of the amino acid alanine which serves as the precursor to carnosine (ß-alanyl-L-histidine) in skeletal muscle.  Supplementing with BA is a highly effective means of increasing muscle carnosine content.  Increased muscle carnosine helps buffer the negative side effects of hydrogen ion accumulation in muscles as exercise intensity increases.
    • Beta-Alanine supplementation has been linked to improved exercise performance and delayed fatigue at higher intensities in both trained and untrained individuals in events lasting 1-4 minutes. 
    • Increases in lean muscle mass and muscular endurance have also been noted with supplementation.
    • A recent meta-analysis confirmed the ergogenic effect of beta-alanine, showing a 2.85% increase in exercise performance compared to placebo when dosed at ~2/grams daily.

    PHARMAPURE CREATINE MONOHYDRATE & CREATINE MAGNAPOWER

    • Creatine is an amino acid (broken down protein) derived compound produced in the body that serves as the primary fuel source (ATP) for short duration, high intensity activities such as sprinting and weight lifting.  Creatine is stored primarily in muscle tissue, and it is used for rephosphorylating ADP into ATP. This means that when our muscles use up our energy stores, creatine helps to replenish those stores in a fairly rapid manner.  Approximately 2 grams of creatine are found in individuals that do not supplement and maintain a diet including animal based proteins.  Those who do supplement can increase their body's internal creatine pool by 10 to 40% depending on diet and total lean muscle mass.
    • As a whole creatine is arguably the most extensively researched and effective supplement available today.  Over 500 studies exist of the ergogenic benefits of creatine supplementation with over 70% of these studies producing significant improvements in performance without any detrimental side effects.
    • Creatine has been proven to increase lean muscle mass, maximal strength, power, and muscular endurance. 
    • Creatine may also help keep you hydrated in extreme outdoor conditions
    • Emerging research suggest creatine may provide cognitive and overall brain health benefits.
    • Creatine MagnaPower is more soluble than creatine monohydrate and in theory should absorb better; requiring a lower dose to achieve the same ergogenic benefits as creatine monohydrate.
    • The ISSN (International Society of Sports Nutrition) position stand on creatine monohydrate (CM) found that short-term CM supplementation has been reported to improve maximal power/strength (5–15%), work performed during sets of maximal effort muscle contractions (5–15%), single-effort sprint performance (1–5%), and work performed during repetitive sprint performance (5–15%). Long-term CM supplementation appears to enhance the overall quality of training, leading to 5 to 15% greater gains in strength and performance.

    BETAINE ANHYDROUS

    • Betaine, scientifically referred to as Trimethylglycine, is a metabolite of choline.  Betaine's two main functions in the body are as a methyl donor and osmolyte.  As an osmolyte, betaine protects proteins, cells, and enzymes from heat, dehydration, and other physiological stresses.  As a methyl donor, betaine is used to convert homocysteine to L-methionine, and is therefore, a precursor to creatine.
    • Doses of 2500-6000mg betaine daily may increase muscular strength, endurance, and total training volume.
    • Betaine also plays a role in hepatic fat metabolism, promoting muscle protein synthesis, and has been suggested to increase nitric oxide levels.
    • A study conducted by the University of Connecticut found that individuals supplementing with 1.25 grams of betaine twice/daily increased bench press power 20%.

    DL MALIC ACID

    • Malic acid plays a vital role in the Krebs cycle where it helps turn carbs, proteins, and fats into energy.
    •  If there is an inadequate supply of malic acid in the body the Krebs cycle cannot function properly which leads to premature fatigue.

    NITRIC OXIDE PUMP MATRIX

    L-CITRULLINE (fermented)(Kyowa Quality)

    • L-Citrulline is an amino acid that plays an important role in nitric oxide metabolism and regulation.
    • It is converted to L-Arginine in the body to support L-Arginine and nitric oxide levels.
    • Increased production of nitric oxide (NO) promotes vascular dilation which improves oxygen and blood circulation throughout the body.
    • L-Citrulline is also expected to relieve muscle fatigue through ammonia elimination.
    • A 2015 study conducted by Bailey et al. found subjects who supplemented with 6000mg L-Citrulline for 7 days were able to improve oxygen uptake and performance during high-intensity exercise.

    AGMATINE SULFATE

    • Agmatine Sulfate is a byproduct of Arginine through decarboxylation. It produces other byproducts that are involved in cell growth, structural and metabolic support to the nervous system. 
    • Decarboxylated arginine cannot be broken down in the liver and consequently increases blood flow to working muscles through vasodilation.
    • Agmatine has also been shown to manipulate pain receptors which may allow you to train past normal pain thresholds.
    • PRE uses a vegan source of agmatine that us derived from fermented plants.

    INOSITOL ARGININE SILICATE (AS NITROSIGINE)

    • Nitrosigine is a bonded complex of arginine and silicon that helps enhance nitric oxide levels to a greater degree compared to arginine alone.
    • Increased nitric oxide levels promote the relaxation of smooth muscle in blood vessels, increasing blood flow to working muscles.
    • In pre-clinical studies nitrosigine was found to be more biologically active than arginine chloride.  The research also showed enhanced blood flow during and after exercise which may help with muscle growth and recovery.

    FOCUS & DRIVE MATRIX

    L-TYROSINE

    • Tyrosine is an essential amino acid whose primary role in the body is as the direct precursor to thyroxine and to the hormones dopamine, epinephrine, and norepinephrine.
    • Tyrosine may improve both endurance and anaerobic performance via metabolic and/or neurotransmitter upregulation.
    • Tyrosine also improves mental acuity, focus, and mood by increasing levels of catecholamines found in the bloodstream.
    • A study done at the Naval Aerospace Medical Research Laboratory reported that a dose of L-Tyrosine, when provided to sleep deprived subjects, ameliorated psychomotor performance declines associated with mental fatigue.

    CHOLINE BITARTRATE (VitaCholine®)

    • Choline Bitartrate is formed when choline is combined with tartaric acid. 
    • This increases the choline's bioavailability and in turn, makes it more effective. 
    • When supplemented, choline bitartrate increases levels of acetylcholine in the body....a neurotransmitter that stimulates muscle contractions and is required for proper memory, cognition, and motor control. 
    • Increasing choline levels can produce a nootropic type effect as well as create longer and stronger muscle contractions.

    HUPERZINE

    • Huperizine A is a selective inhibitor of the neurotransmitter acetylcholinesterase (AChE), which means it prevents the breakdown and increases the amount of acetylcholine; an important neurotransmitter in the central nervous system involved in cognition and muscular contractions. 
    • Multiple studies have shown that supplementation with Huperzine-A can enhance focus, memory and mood.
    • A study conducted by Sun et al. (1999) reported that subjects who supplemented with Huperzine A for 4 weeks improved learning performance and memort compared to a placebo group.

    ELECTROLYTE & HYDRATION OPTIMIZER

    TAURINE

    • Taurine is one of the most important, useful, and safest amino acids.  Taurine is best known for its beneficial effects on the heart and cardiovascular system. Early clinical research also suggests that taurine, in combination with caffeine, can produce improvements in mental performance.  When the body engages in extreme physical activity, it no longer will be able to produce the necessary amounts of taurine, therefore supplementation becomes necessary.
    • Taurine is involved in the regulation of core body temperature and may help prevent heat stress and stroke.
    • Taurine is also acts is an osmolyte; assisting the body in maintaining proper water balance.
    • Zhang et al. (2004) found that individuals who supplemented with taurine for 1 week before an exhaustive exercise bout significantly improved time to exhaustion, VO2 max, and maximal workload. It also decreased exercise induced DNA damage.

    CALCIUM POTASSIUM PHOSPHATE CITRATE (AS CALCI-K) & SODIUM PHOSPHATE

    • Calcium, potassium, and phosphorus are vital electrolytes needed to maintain bodily water balance and facilitate motor neuron function.
    • The combination of these electrolytes in CALCI-K are highly soluble and readily absorbed by the body.
    • Electrolytes have been shown to prevent muscle cramps and are essential to normal muscular contractions.
    • As we exercise electrolytes are lost through sweat and must be replaced in order to prevent decreases in performance
    • Sims et al. (2007) discovered that pre-exercise ingestion of a high-sodium beverage increased plasma volume before exercise and involved less thermoregulatory and perceived strain during exercise and increased exercise capacity in warm conditions.

    PRE Stim-Free FAQs

    What is the best way to take PRE Stim-Free?

    • Mix one heaping scoop of PRE into 12-14 ounces of water and consume 30-45 minutes prior to training.

    Aren't stimulants the only thing that make pre-workouts effective? Why wouldn't you put them in the formula?

    • Absolutely not. While there is no doubt that certain stimulants such as caffeine can improve performance, they are not the only ingredients in a pre-workout that provide an ergogenic benefit.  For example, the creatine found in PRE Stim-Free is the most studied and effective performance boosting supplement ever and is not considered a stimulant.  We left stimulants out of this formula to accommodate individuals who are sensitive to stimulants, hit the gym late at night, or otherwise want a performance enhancing pre-workout without stimulants.

    I heard creatine can cause kidney problems and cause cramping.  Is that true?

    • Absolutely not.  Creatine is the most studied and effective supplement ever...period.  Over 500 studies have been done on creatine and none have shown to cause any adverse side effects. However, you should expect to see big improvements in strength, power, and endurance after taking creatine.

    What makes PRE Stim-Free better than other stimulant free pre-workouts?

    • A lot of other stimulant free pre-workouts use ingredients that are ineffective or not properly dosed.  All the ingredient in PRE Stim-Free are research backed and dosed efficaciously based on the current scientific literature.

    PRE Workout Stimulant Free Supplement Facts Panel, Label Image, and Suggested Use

    Ingredients may change from time to time as we update our products. Please check the label on the bottle.

    Label Image for NutraBio PRE Workout Stimulant Free
    Supplement Facts Panel for NutraBio PRE Workout Stimulant Free

    Suggested Use: As a dietary supplement, mix 1 heaping scoop of PRE into 12-14 ounces of water and consume 30-45 minutes prior to resistance training. Vary the amount of water to achieve your desired flavor level. DO NOT EXCEED 1 SCOOP IN ANY 24 HOUR PERIOD OR USE MORE THAN 5 DAYS IN ANY 7 DAY PERIOD.

    WARNING: KEEP OUT OF REACH OF CHILDREN. This product is only intended to be consumed by healthy adults 18 years of age or older. Do not use if you are pregnant, breast feeding, have known medical conditions (including but not limited to kidney, heart or liver disease) or are taking prescription or OTC medication(s). Consult with your health care practitioner before using this product. Do not use under extreme conditions of heat, CARDIOVASCULAR EXERTION or dehydration. Discontinue use and consult with your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving.

    PRE Workout Stimulant Free Dietary Restriction Information

    PRE Workout Stimulant Free is...
    Please check individual labels. Flavors may vary.
    OU KosherCertified Kosher by the Orthodox Union.
    VegetarianDoes not contain animal or dairy products.
    HypoallergenicXMay contain allergens.
    Gluten FreeDoes not contain gluten. Suitable for individuals on a gluten free diet.
    Non-GMODoes not contain genetically modified organisms (GMOs).
    Filler FreeAbsolutely no fillers.
    Excipient FreeAbsolutely no excipients or chemical additives.
    BSE/TSE FreeFree of Bovine Spongiform Ecephalopathy (BSE) and Transmissible Spongiform Encephalopathy (TSE).
    GMPManufactured in the United States in NutraBio's FDA registered and inspected facility to meet FDA 21 CFR Part 111 c-GMP regulations.
    Full Label DisclosureFull label disclosure guaranteed!. Every ingredient in this product is declared on the label. In addition, the exact quantity of each active ingredient is declared on the label. No ingredients are hidden in proprietary blends, so you know exactly what's in the product.


    We guarantee our supplements to be the freshest and purest: Our powders and capsules contain only pure active ingredient with absolutely no additives. Other manufacturers, in an effort to keep costs down, dilute their products with cheap fillers and add chemical excipients to their products to speed up their manufacturing output. These practices cheat you out of the active ingredient. At NutraBio, we've perfected our manufacturing technology so that excipients aren't needed, that means no microcrystalline cellulose, magnesium stearate, silica or other fillers, just 100% pure active ingredient. NutraBio supplements are manufactured under the strictest standards producing the highest quality and purest supplements available anywhere. Our raw ingredients undergo state of the art HPLC analysis to insure zero tolerance for impurities and we manufacture our products every 2 weeks.

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    PRE Research:

    1. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine,36(4), 282-289.
    2. Hickner, R. C., Tanner, C. J., Evans, C. A., Clark, P. D., Haddock, A., Fortune, C., ... & Mccammon, M. (2006). L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Medicine and science in sports and exercise, 38(4), 660-666.
    3. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
    4. Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-citrulline-malate influence over branched chain amino acid utilization during exercise. European journal of applied physiology, 110(2), 341-351.
    5. Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25-37.
    6. Stout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D., Costa, P., Hoffman, J. R., ... & O'kroy, J. (2007). Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino acids,32(3), 381-386.
    7. Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., ... & Stout, J. R. (2009). Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. Journal of the International Society of Sports Nutrition, 6(1), 1-9.
    8. Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. Journal of Applied Physiology, 109(4), 1096-1101.
    9. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., ... & Campbell, B. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12(1), 1-14.
    10. Norton, L. E., & Layman, D. K. (2006). Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. The Journal of nutrition, 136(2), 533S-537S.
    11. Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., ... & Mawatari, K. (2010). Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness.International journal of sport nutrition, 20(3), 236.
    12. Nicastro, H., Artioli, G. G., dos Santos Costa, A., Solis, M. Y., Da Luz, C. R., Blachier, F., & Lancha Jr, A. H. (2011). An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids, 40(2), 287-300.
    13. Howatson, G., Hoad, M., Goodall, S., Tallent, J., Bell, P. G., & French, D. N. (2012). Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr, 9(1), 20.
    14. Apicella, J. M., Lee, E. C., Bailey, B. L., Saenz, C., Anderson, J. M., Craig, S. A., ... & Maresh, C. M. (2013). Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.European journal of applied physiology, 113(3), 793-802.
    15. Trepanowski, J. F., Farney, T. M., Mccarthy, C. G., Schilling, B. K., Craig, S. A., & Bloomer, R. J. (2011). The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. The Journal of Strength & Conditioning Research, 25(12), 3461-3471.
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    22. Lopez, R. M., Casa, D. J., McDermott, B. P., Ganio, M. S., Armstrong, L. E., & Maresh, C. M. (2009). Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses. Journal of athletic training, 44(2), 215-223.
    23. Candow, D. G., Chilibeck, P. D., Burke, D. G., Mueller, K. D., & Lewis, J. D. (2011). Effect of different frequencies of creatine supplementation on muscle size and strength in young adults. The Journal of Strength & Conditioning Research, 25(7), 1831-1838.
    24. McConell, G. K., Shinewell, J., Stephens, T. J., Stathis, C. G., Canny, B. J., & Snow, R. J. (2005). Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans. Medicine and science in sports and exercise, 37(12), 2054.
    25. Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial. Proceedings of the Royal Society of London B: Biological Sciences, 270(1529), 2147-2150.
    26. Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., Yamagami, T., Liu, Z., & Qi, B. (2004). Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino acids, 26(2), 203-207.
    27. BOUCHAMA, A., YUSUF, A., AL-SEDAIRY, S. U. L. T. A. N., & EL-YAZIGI, A. D. N. A. N. (1993). Alteration of taurine homeostasis in acute heatstroke.Critical care medicine, 21(4), 551-554.
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    36. Xiao, X. Q., Yang, J. W., & Tang, X. C. (1999). Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury.Neuroscience letters, 275(2), 73-76.
    37. Malkova, L., Kozikowski, A. P., & Gale, K. (2011). The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.Neuropharmacology, 60(7), 1262-1268.
    38. Kitisripanya, N., Saparpakorn, P., Wolschann, P., & Hannongbua, S. (2011). Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method. Nanomedicine: Nanotechnology, Biology and Medicine,7(1), 60-68.
    39. Sun, Q. Q., Xu, S. S., Pan, J. L., Guo, H. M., & Cao, W. Q. (1999). Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo yao li xue bao= Acta pharmacologica Sinica, 20(7), 601-603.
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