L-Tyrosine Alpha-Ketoglutarate (2:1)

Pharmaceutical grade ultra-pure for maximum bioavailability.
Pure AKG amino acid with no fillers or additives. HPLC verified.

L-Tyrosine is an essential amino acid which supports brain function. It can be converted by neurons in the brain into te neurotransmitters dopamine and norepinephrine (noradrenaline), hormones which are depleted by stress, excessive work and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. L-tyrosine boosts certain neurotransmitters in the brain and has been used to support stress reduction and depression. L-Tyrosine is converted in the body into other key biologic compounds, including L-dopa, CoQ10, thyroid hormones and melanin.

The amino acid L-Tyrosine is a precursor for several substances made in the body including:

• Neurotransmitters such as dopamine and norepinephrine
• Melanins, the pigments largely responsible for skin and hair color
• Thyroid hormones, such as thyroxine

Powder Kosher	150 Grams (150 Servings)	Item #24600	$14.89 Retail: $34.99	save 58%
	500 Grams (500 Servings)	Item #24601	$25.83 Retail: $89.99	save 70%
	1,000 Grams (1000 Servings)	Item #24602	$46.97 Retail: $179.98	save 75%
	2268 Grams (2268 Servings)	Item #24603	$89.99 Retail: $399.99	save 80%
500 mg Capsules	150 Caps (75 Servings)	Item #24606	$14.78 Retail: $39.99	save 63%
	500 Caps (250 Servings)	Item #24607	$39.96 Retail: $129.99	save 69%
	1,000 Caps (500 Servings)	Item #24608	$63.98 Retail: $259.99	save 76%
	5,000 Caps (2500 Servings)	Item #24609	$219.99	save 84%

This product is Hypoallergenic & Pharmaceutical Grade

Powder is Kosher Pareve & Vegetarian

Click here to view the Orthodox Union Kosher certification.

Tyrosine can also enhance athletic performance. L-Tyrosine is an important component of protein and helps form the bioactive factors vital to cellular growth and maintenance. Tyrosine supplementation has the potential to increase athletic performance in a few ways. One of the mechanisms possibly contributing to fatigue during exercise is an increase in central serotonin levels and an increase in the ratio of serotonin to dopamine. Tyrosine may help decrease this ratio and compete with tryptophan (the amino acid precursor to serotonin) at the blood-brain barrier. Increased dopaminergic activity may decrease the perception of fatigue. Also, during highly stressful conditions, catecholamine levels can become depleted, and tyrosine may be particularly useful under these conditions.

NutraBio.com L-Tyrosine is pure free form crystalline amino acid from microbiological fermentation. It is NOT derived from milk. The B vitamins pyridoxine (B-6) and folic acid can assist in the conversion process.

Benefits of Alpha-Ketoglutarate (AKG) Amino Acids:

Amino Acid Alpha-Ketoglutarates are amino acids with an alpha-ketoglutaric acid (AKG) molecule attached. This AKG transport molecule helps the amino acid bypass the gut and enter the muscle cell directly giving you superior absorption. Unlike L- form amino acids, AKGs are shuttled directly to the muscle cells rather than being absorbed and used by the small intestines for nucleotide synthesis. AKG drives the amino acid into cells creating a pro-anabolic environment.

Amino acid alpha-ketoglutarates are technically amino acids derivatives. Their ergogenic effects are similar to those of their base free form amino acids, but by molecularly bonding it to AKG, its ergogenic effects become more pronounced within the muscle cell itself. The presence of the AKG molecule not only enhances the function of amino acid and overcomes its inherent limitations, but also increases its absorption rate thereby reducing the need for large doses, which may put less stress on the body. An added benefit is that AKG is a precursor to glutamine, so when the AKG is finished doing its job as a shuttle molecule it gets converted into glutamine. No waste - all benefit.

Also available:

• L-Tyrosine (free form)
• L-Tyrosine Ethyl Ester

We guarantee our supplements to be the freshest and purest: Our powders and capsules contain only pure active ingredient with absolutely no additives. Other manufacturers, in an effort to keep costs down, dilute their products with cheap fillers and add chemical excipients to their products to speed up their manufacturing output. These practices cheat you out of the active ingredient. At NutraBio, we've perfected our manufacturing technology so that excipients aren't needed, that means no microcrystalline cellulose, magnesium stearate, silica or other fillers, just 100% pure active ingredient. NutraBio supplements are manufactured under the strictest standards producing the highest quality and purest supplements available anywhere. Our raw ingredients undergo state of the art HPLC analysis to insure zero tolerance for impurities.	Expiration	30 months minimum
	Grade	pharmaceutical
	Purity	99.84%+ purity (HPLC)
	Taste	sour taste
	Solubility	good - mixes easy in water
	Characteristics	no cramping or bloating
	Appearance	off white powder
	Odor	none/slight
	pH	n/a
	Classification	(Amino Acid)
	CAS Registry	n/a
	Synonyms	L-Tyrosine AKG

Suggested Usage for Tyrosine AKG

As a dietary supplement, take 1 gram mixed in water or juice between meals 1 to 2 times daily, or as directed by your health care professional. If you experience stomach irritation, take with meals. Tyrosine ethyl ester is nontoxic and well-absorbed. This pure powdered form mixes well with juice or water. No daily Values have been established for glycine.

Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult healthy adults only.

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NutraBio Pure
An unprecedented commitment to
quality, purity and freshness since 1996!

We manufacture in our own FDA registered and inspected GMP facility:

Since 1996, NutraBio has manufactured the purest pharmaceutical grade products available. We manufacture in the United States in our own FDA registered and inspected facility to meet FDA 21 CFR Part 111 cGMP regulations. All ingredients undergo state-of-the-art analysis to insure zero tolerance for impurities.

Truthful and Clear Supplement Facts Panels - No BS Proprietary Blends:

A proprietary blend is a cheap gimmick used by manufacturers to hide the real truth about what's in their product. By listing a bunch of ingredients under one blend on the label, the manufacturer only has to tell you how much of the blend is in a serving while hiding how much of each ingredient is in a serving. They pretend to this to protect their secret formula, that’s bull, they do it so they can cheapen their product without their customers knowing. In the industry we call this “Window Dressing” the product the label looks good on the outside but there is nothing really happening on the inside. At NutraBio our Supplement Facts panels list the exact amount of each and every active ingredient in the supplement. No guessing, you know exactly what you are getting in every product we sell.

Purchase manufacturer direct at wholesale price:

Buy directly from the manufacturer and save. We cut out the middlemen and pass the savings on to you. With NutraBio, you pay the same low wholesale price that the chain stores pay. Did you know that most companies do not manufacture their products but use 3rd party manufacturers? Since we manufacture all of our own products we can control the quality and purity through the entire manufacturing process. We never sell old or near expired products.

rev-2011

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References & research:

[1] Tyrosine (and N-Acetyl-L-Tyrosine) [PDF, 232KB] Reform Magazine online John M. Berardi
[2] Hair pigmentation: a research update. J Investig Dermatol Symp Proc. 2005 Dec;10(3):275-9 Tobin DJ, Hordinsky M, Bernard BA
[3] The actions of melanin and melanocyte stimulating hormone (MSH) Neuroendocrinology Letters 1999; 20:265–282 Natalie Rasmussen, Francine Nelson, Piyarat Govitrapong, Manuchair Ebadi
[4] Melanin [monograph] Wikipedia online encyclopedia
[5] Tyrosine [monograph] Wikipedia online encyclopedia
[6] Dopaminergic deficit and mood disorders. Int Clin Psychopharmacol. 2002 Dec;17 Suppl 4:S1-7; discussion S7 Pania L, Gessab GL
[7] Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology. 2005;52(2):90-110. Epub 2005 Jul 19 Willner P
[8] [L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies][Article in French] C R Acad Sci III. 1988;306(3):93-8 Mouret J, Lemoine P, Minuit MP, Robelin N
[9] Tyrosine for the treatment of depression. Nutr Health. 1984;3(3):163-73 Gelenberg AJ, Gibson CJ
[10] Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999 Jan 15;48(2):203-9 Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ.
[11] Cats require more dietary phenylalanine or tyrosine for melanin deposition in hair than for maximal growth. J Nutr. 2002 Jul;132(7):2037-42 Anderson PJ, Rogers QR, Morris JG
[12] Vitiligo therapy with oral and topical phenylalanine with UVA exposure. Int J Dermatol. 1989 Oct;28(8):545-7 Antoniou C, Schulpis H, Michas T, Katsambas A, Frajis N, Tsagaraki S, Stratigos J
[13] Evidence for antioxidant nutrients-induced pigmentation in skin: results of a clinical trial. Biochem Mol Biol Int. 1997 Aug;42(5):1023-33 Postaire E, Jungmann H, Bejot M, Heinrich U, Tronnier H
[14] Stimulation of mouse melanocyte proliferation by Piper nigrum fruit extract and its main alkaloid, piperine. Planta Med 1999 Oct;65(7):600-3 Lin Z, Hoult JR, Bennett DC, Raman A
[15] Chronic dietary tyrosine supplements do not affect mild essential hypertension. Hypertension. 1985 Jul-Aug;7(4):593-6 Sole MJ, Benedict CR, Myers MG, Leenen FH, Anderson GH
[16] [L-tyrosine: a long term treatment of Parkinson's disease][Article in French] C R Acad Sci III. 1989;309(2):43-7 Lemoine P, Robelin N, Sebert P, Mouret J