TMG (Trimethylglycine / Betaine anhydrous)

Pharmaceutical grade for maximum bioavailability. 99.98% pure with no fillers or additives. HPLC verified.

TMG supplementation has been shown in clinical and non-clinical studies to support a healthy homocysteine level, which in turn supports healthy cardiovascular function. In a recent study, participants who consumed 360 mg of betaine had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of Creactive protein than did those who consumed 260 mg. (17)

Supports healthy homocysteine levels.
Supports a healthy cardiovascular system.
Supports healthy blood vessels.
Supports healthy liver function.
Protects liver cells from toxins and helps process fats.
Support normal levels of S-adenosyl-methionine (SAMe) in the cerebrospinal fluid.
Assists homocysteine to be metabolized into methionine, resulting in the production of dimethylglycine (DMG).

Powder Kosher	150 Grams (150 Servings)	Item #24610	$6.95	save 60%
	500 Grams (500 Servings)	Item #24611	$18.50	save 60%
	1000 Grams (1000 Servings)	Item #24612	$33.50	save 70%
	2500 Grams (2500 Servings)	Item #24613	$73.70	save 80%
500 mg Capsules	150 Caps (75 Servings)	Item #24616	$8.53	save 60%
	500 Caps (250 Servings)	Item #24617	$25.59	save 68%
	1,000 Caps (500 Servings)	Item #24618	$46.72	save 72%
* Freshness Guarantee: To maintain product freshness we ship this product in multiples of 500 Gram or 500 Capsule bottles. For example if you order 1000 Grams you'll receive 2 bottles of 500 Grams each. Use the first bottle while the second stays sealed and fresh.

This product is Kosher Pareve in powder form only.
This product is also Hypoallergenic and Pharmaceutical Grade.

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What is TMG (Trimethylglycine) and what does TMG do?

Trimethylglycine (TMG) protects the cardiovascular system by neutralizing harmful homocysteine while offering valuable nutritional support for healthy liver function. TMG acts as a "methyl donor," providing extra methyl groups to hasten the conversion of harmful homocysteine into the biologically safe and beneficial amino acid methionine. Methyl donors, such as TMG and folic acid, are required for converting homocysteine back into methionine and for the accurate synthesis of DNA and RNA, which is essential for the production of normal cells. When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine, and then into S-adenosyl-methionine (SAMe).

Impairment of methylation results in abnormal cell synthesis and elevated levels of homocysteine, a toxic amino acid and a serious health risk. Methylation can be inhibited by inadequately functioning key enzymes, excessive protein and fat intake, poor diet, inadequate intake of methyl groups, coffee, alcohol or by smoking.

TMG, also known as betaine anhydrous, acts as a methyl donor which is important for a wide range of physiological reactions in the body. TMG works closely with other methyl donors including choline, folic acid, vitamin B12 and s-adenosyl-methionine (SAMe), and is also a precursor of carnitine synthesis.

TMG may help protect the liver against the effects of alcohol, possibly by stimulating the formation of SAMe. TMG may be helpful for non-alcoholic forms of fatty liver (non-alcoholic steatosis). (20,21,22,25,26,27)

In the course of its metabolism in the body, TMG is turned into dimethylglycine (DMG). In Russia, DMG is used extensively as an athletic performance enhancer, and it has recently become popular among American athletes. TMG is a less expensive alternative that may have the same effects as DMG as it does convert into DMG in the body. (31)

TMG has also been suggested as a less expensive substitute for S-adenosyl-methionine (SAMe) for conditions for which SAMe is used, such as osteoarthritis and depression. However, there is no evidence to show that it is effective for these purposes.

TMG, also known as betaine anhydrous, is extracted from sugar beets.

We guarantee our supplements to be the freshest and purest: Our powders and capsules contain only pure active ingredient with absolutely no additives. Other manufacturers, in an effort to keep costs down, dilute their products with cheap fillers and add chemical excipients to their products to speed up their manufacturing output. These practices cheat you out of the active ingredient. At NutraBio, we've perfected our manufacturing technology so that excipients aren't needed, that means no microcrystalline cellulose, magnesium stearate, silica or other fillers, just 100% pure active ingredient. NutraBio supplements are manufactured under the strictest standards producing the highest quality and purest supplements available anywhere. Our raw ingredients undergo state of the art HPLC analysis to insure zero tolerance for impurities.	Expiration	30 months minimum
	Grade	pharmaceutical
	Purity	99.98%+ purity (HPLC)
	Taste	tart
	Solubility	soluble in water
	Appearance	white to off white crystalline powder
	pH	5.5~7.0
	Classification	methyl donor
	CAS Registry	107-43-7
	Synonyms	betaine; betaine anhydrous; 2-(trimethylammonio)ethanoic acid hydroxide inner salt; (carboxymethyl)trimethylammonium hydroxide inner salt; glycine betaine; Methanaminium; trimethylammonioacetate
	Molecular Formula	C₅H₁₁NO₂
	Molecular structure

Amino acids

NutraBio Supplement Facts Panel TMG Trimethyglycine

Suggested Usage: As a dietary supplement, take 1 gram 1 to 3 times daily, preferably with meals, or as directed by your qualified health consultant.

Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements. If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside. People with high or borderline-high cholesterol should use TMG under the supervision of their physician.

References & research:

1. Ann West Med Surg. 1951;5:830-55.
2. Ann West Med Surg. 1951;5:856-62.
3. JAMA. 1951;145:1232-6.
4. Am J Dig Dis. 1952;19:381-4.
5. Lawson-Yuen A et al. 2006
6. Biochemistry. 1999 Oct 19;38(42):13991-8.
7. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
8. J Nutr. 2003 Dec;133(12):4135-8.
9. J Nutr. 2003 May;133(5):1291-5.
10. American Journal of Clinical Nutrition 2002 Nov;76(5):961-7.
11. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
12. Kidney Int. 2002 Mar;61(3):1040-6.
13. An Esp Pediatr. 1993 Jul;39(1):37-41.
14. Metabolism. 1985 Dec;34(12):1115-21.
15. New England Journal of Medicine. 1983 Aug 25;309(8):448-53.
16. J Nutr. 2006 Jan;136(1):34-8.
17. American Journal of Clinical Nutrition 2008;87:424-30.
18. Ann West Med Surg. 1951;5:825-9. 19. Wilcken DEL, Dudman NPB, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency—the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985;34:1115-1121.
20. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol and the liver: a review. Alcohol. 1996;13:395-398.
21. Barak AJ, Beckenhauer HC, Junnila M, et al. Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res. 1993;17:552-555.
22. Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol. 1998;44:249-255.
23. Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc. 1982;14:424-427.
24. Mangoni AA, Jackson SH. Homocysteine and cardiovascular disease: current evidence and future prospects. Am J Med. 2002;112:556-565.
25. Kanbak G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective effect of betaine. Cell Biochem Funct. 2001;19:281-285.
26. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol. 2001;96:2711-2717.
27. Angulo P, Lindor KD. Treatment of nonalcoholic fatty liver: present and emerging therapies. Semin Liver Dis. 2001;21:81-188.
28. Schwab U, Torronen A, Meririnne E et al. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr. 2005;136:34-38.
29. Olthof MR, Van Vliet T, Boelsma E et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003;133:4135-4138.
30. Olthof MR, Vliet TV, Verhoef P et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med. 2005;2:e135.
31. Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc. 1982;14:424-427.

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Since 1996, NutraBio has manufactured the purest pharmaceutical grade products available. We manufacture in the United States in our own FDA registered and inspected facility to meet FDA 21 CFR Part 111 cGMP regulations. All ingredients undergo state-of-the-art analysis to insure zero tolerance for impurities.

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