RIBOSE™ in Sports Nutrition
exercise drains energy from muscle and places a great strain on the
heart leading to diastolic dysfunction that can persist for several
weeks to months following an athletic event. Bioenergy RIBOSE can help
hearts and muscles accelerate energy recovery, reduce fatigue
post-exercise malaise, and improve exercise performance over time.
muscle, high-intensity exercise can lead to a loss of up to 26% of
cellular adenosine triphosphate, or ATP. A certain portion of this
energy is quickly replaced as the muscle recovers, but up to 40% of the
depleted ATP is washed out of the cell and lost. Normally, this lost
energy can be restored with rest lasting for more than three days, but
if exercise continues the cell may not fully recover on its own. Over
time, this progressive energy loss can affect cell and muscle function
and affect athletic performance.
Another consequence of this energy drain is an increase in free radicals
in affected muscle. Free radicals attack cell and mitochondrial
membranes and can destroy the genetic material that helps muscle tissues
synthesize proteins. It also depletes the cell of energy it needs to
increase lean muscle mass.
Bioenergy RIBOSE helps in three ways. First, if enough ribose is present
in the cell or the circulating blood, energy compounds can be saved, or
salvaged, before they wash out of the cell and are lost. Second, ribose
accelerates energy synthesis, so if energy compounds are lost, they can
be quickly replaced. Finally, by keeping the energy compounds in the
cell, Bioenergy RIBOSE reduces free radical formation and preserves the
energy the tissue needs to make proteins essential for maintaining
muscle health and performance.
Skeletal muscle lacks the metabolic capacity to make ribose quickly when
muscles are stressed. Supplementing with Bioenergy RIBOSE gives the
muscle the ribose it needs to make ATP and restore the energy charge of
the cell. Research has shown that in mixed muscle, ribose can increase
energy salvage by up to 8-fold and accelerate ATP synthesis by up to
4.3-fold. This means that muscle can recover in one to three days,
rather than the three to seven days seen in muscle not supplemented with
And this energy improvement has been shown to translate to increased
performance over time. A study published in the journal, Current
Therapeutic Research, showed that male recreational bodybuilders
experienced a significant improvement in both strength and endurance
following 28 days of Bioenergy RIBOSE supplementation. While
placebo-treated athletes showed an improvement in both parameters, the
improvements were not statistically significant.
Bioenergy RIBOSE is not a stimulant, and it does not provide a
functional or performance benefit from one exercise bout to another, or
following only a few days of supplementation. Instead, what Bioenergy
RIBOSE does is keep the muscle energy level high so the muscle stays in
top physiological condition. In the short term, this helps overcome
post-exertional fatigue and soreness and reduces the "spongy" legs and
weakness that frequently follows an extended training bout. Over the
longer term, it can translate to better training and enhanced athletic
To learn more about how Bioenergy RIBOSE can enhance exercise recovery
and improve performance, refer to the following:
Ribose Dose Suggestions for Sports
Ribose increases both de
novo (new) synthesis and salvage of nucleotides in heart and skeletal
muscle. Laboratory research has shown that even low doses of ribose have
a dramatic effect on adenine nucleotide metabolism.
Suggested dosage depends,
in part, on the degree of physical activity performed and the expected
result of the ribose supplementation. To help maintain normal tissue
energy pools and enhance muscle recovery following exercise, doses of 2
– 5 grams per day taken before or after exercise or activity are
adequate. However, research has shown that larger doses of 7.5 to 10
grams have the effect of improving athletic performance.
For best effect, ribose
should be taken before and after exercise or activity. If long duration
exercise is anticipated, additional doses may be taken during exercise.
If ribose can only be taken in one dose, it is recommended that it be
taken immediately following exercise, since most nucleotides are lost
from tissue upon rest following strenuous activity.
Virtually all forms of
exercise lead to conditions associated with loss of nucleotides from
tissue. High intensity exercise, such as bodybuilding, sprinting, long
distance cycling, rowing or running in hilly terrain causes frequent
periods of hypoxic or anaerobic cellular metabolism creating
physiological conditions that significantly depress the adenine
nucleotide pool. In fact, catecholamines released by tissues during
exercise may lead to a general loss of nucleotides, even from muscle
that is not being exercised at the time.
Ribose does not build up in
tissue and does not reside in the bloodstream for extended periods.
Therefore, daily maintenance doses of ribose are not required. However,
if frequent bouts of high intensity exercise are performed, ribose
administration on off days may help normalize energy pools more quickly.