Bioenergy RIBOSE™ in Sports Nutrition

Strenuous, high-intensity exercise drains energy from muscle and places a great strain on the heart leading to diastolic dysfunction that can persist for several weeks to months following an athletic event. Bioenergy RIBOSE can help hearts and muscles accelerate energy recovery, reduce fatigue post-exercise malaise, and improve exercise performance over time.

In skeletal muscle, high-intensity exercise can lead to a loss of up to 26% of cellular adenosine triphosphate, or ATP. A certain portion of this energy is quickly replaced as the muscle recovers, but up to 40% of the depleted ATP is washed out of the cell and lost. Normally, this lost energy can be restored with rest lasting for more than three days, but if exercise continues the cell may not fully recover on its own. Over time, this progressive energy loss can affect cell and muscle function and affect athletic performance.

Another consequence of this energy drain is an increase in free radicals in affected muscle. Free radicals attack cell and mitochondrial membranes and can destroy the genetic material that helps muscle tissues synthesize proteins. It also depletes the cell of energy it needs to increase lean muscle mass.

Bioenergy RIBOSE helps in three ways. First, if enough ribose is present in the cell or the circulating blood, energy compounds can be saved, or salvaged, before they wash out of the cell and are lost. Second, ribose accelerates energy synthesis, so if energy compounds are lost, they can be quickly replaced. Finally, by keeping the energy compounds in the cell, Bioenergy RIBOSE reduces free radical formation and preserves the energy the tissue needs to make proteins essential for maintaining muscle health and performance.

Skeletal muscle lacks the metabolic capacity to make ribose quickly when muscles are stressed. Supplementing with Bioenergy RIBOSE gives the muscle the ribose it needs to make ATP and restore the energy charge of the cell. Research has shown that in mixed muscle, ribose can increase energy salvage by up to 8-fold and accelerate ATP synthesis by up to 4.3-fold. This means that muscle can recover in one to three days, rather than the three to seven days seen in muscle not supplemented with ribose.

And this energy improvement has been shown to translate to increased performance over time. A study published in the journal, Current Therapeutic Research, showed that male recreational bodybuilders experienced a significant improvement in both strength and endurance following 28 days of Bioenergy RIBOSE supplementation. While placebo-treated athletes showed an improvement in both parameters, the improvements were not statistically significant.

Bioenergy RIBOSE is not a stimulant, and it does not provide a functional or performance benefit from one exercise bout to another, or following only a few days of supplementation. Instead, what Bioenergy RIBOSE does is keep the muscle energy level high so the muscle stays in top physiological condition. In the short term, this helps overcome post-exertional fatigue and soreness and reduces the "spongy" legs and weakness that frequently follows an extended training bout. Over the longer term, it can translate to better training and enhanced athletic performance.

To learn more about how Bioenergy RIBOSE can enhance exercise recovery and improve performance, refer to the following:

Ribose Dose Suggestions for Sports Nutrition

Ribose increases both de novo (new) synthesis and salvage of nucleotides in heart and skeletal muscle. Laboratory research has shown that even low doses of ribose have a dramatic effect on adenine nucleotide metabolism.

Suggested dosage depends, in part, on the degree of physical activity performed and the expected result of the ribose supplementation. To help maintain normal tissue energy pools and enhance muscle recovery following exercise, doses of 2 – 5 grams per day taken before or after exercise or activity are adequate. However, research has shown that larger doses of 7.5 to 10 grams have the effect of improving athletic performance.

For best effect, ribose should be taken before and after exercise or activity. If long duration exercise is anticipated, additional doses may be taken during exercise. If ribose can only be taken in one dose, it is recommended that it be taken immediately following exercise, since most nucleotides are lost from tissue upon rest following strenuous activity.

Virtually all forms of exercise lead to conditions associated with loss of nucleotides from tissue. High intensity exercise, such as bodybuilding, sprinting, long distance cycling, rowing or running in hilly terrain causes frequent periods of hypoxic or anaerobic cellular metabolism creating physiological conditions that significantly depress the adenine nucleotide pool. In fact, catecholamines released by tissues during exercise may lead to a general loss of nucleotides, even from muscle that is not being exercised at the time.

Ribose does not build up in tissue and does not reside in the bloodstream for extended periods. Therefore, daily maintenance doses of ribose are not required. However, if frequent bouts of high intensity exercise are performed, ribose administration on off days may help normalize energy pools more quickly.


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