L-Histidine is an essential amino acid, which converts to histamine, a powerful blood vessel dilator, involved in gastric acid secretions and neurotransmission in the central nervous systems. It is also related to circadian rhythms, sexual arousal and orgasmic function in women.

L-Histidine is needed for growth and for the repair of tissue, as well as the maintenance of the myelin sheaths that act as protector for nerve cells. It is known to help protect the body from damage caused by radiation and also helps in removing heavy metals from the body. L-histidine is also required by the body to regulate and utilize essential trace minerals such as copper, zinc, iron, manganese and molybdenum.

L-Histidine is precursor to the allergy symptom producing hormone histamine. Histamine is well known for its role in stimulating the inflammatory response of skin and mucous membranes such as those found in the nose - this action is essential in the protection of these barriers during infection.

L-Histidine is an essential amino acid, which converts to histamine, a powerful blood vessel dilator, involved in gastric acid secretions and neurotransmission in the central nervous systems. It is also related to circadian rhythms and sexual arousal and orgasmic function in women.

L-Histidine is needed for growth and for the repair of tissue, as well as the maintenance of the myelin sheaths that act as protector for nerve cells. It is known to help protect the body from damage caused by radiation and also helps in removing heavy metals from the body.

L-Histidine is precursor to the allergy symptom producing hormone histamine. Histamine is well known for its role in stimulating the inflammatory response of skin and mucous membranes such as those found in the nose - this action is essential in the protection of these barriers during infection.

Histamine also stimulates the secretion of the digestive enzyme gastrin. Without adequate histamine production healthy digestion can become impaired. Without adequate In the stomach, L-Histidine can be helpful in producing gastric juices. People with a shortage of gastric juices or suffering from indigestion, may also benefit from this nutrient.

L-Histidine is also required by the body to regulate and utilize essential trace minerals such as copper, zinc, iron, manganese and molybdenum.

L-Histidine is one of the glucogenic amino acids.  Glucogenic amino acids facilitate the body's production of energy. L-Histidine is used to help boost the production of red and white blood cells.

Research has shown that increased supplementation of L-Histidine can cause increased secretion and elimination of zinc from the human body so supplementing with zinc when taking L-Histidine is recommended.

Low levels of L-Histidine have been associated with Rheumatoid Arthritis, and anemia.

Suggested Usage: As a dietary supplement, take 1 or 2 servings with water or your favorite beverage up to 2 times daily between meals, or as directed by your physician.  Read all warning before taking L-Histidine. Because increased supplementation of L-Histidine causes secretion and elimination of zinc from the human body to significantly increase, many researchers suggest supplementing with zinc when taking L-Histidine.

Kosher, Vegetarian and Hypoallergenic: Free of the most common allergens such as yeast, dairy, egg, gluten, corn, soy, rice, barley, lactose, fish and wheat. No added sugars, starch, salt, preservatives, salicylates, or artificial color, flavor or fragrance.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements. There are no reported side effects with L-Histidine, but too high levels of it may lead to stress and mental disorders such as anxiety and people with schizophrenia have been found to have high levels of histidine. People suffering from schizophrenia or bipolar (manic) depression should not take a histidine supplement without the approval of their medical professional.

References & Further Research

Evidence that histidine is an essential amino acid in normal and chronically uremic man:
The requirement for dietary histidine was investigated in four normal and three chronically uremic men. After administration of the histidine-repletion diet, nitrogen balance became positive in six subjects; serum albumin increased in five cases; plasma and muscle histidine rose; serum iron fell abruptly; a reticulocytosis ensued; and the hematocrit rose. The clinical symptoms and skin lesions disappeared. These observations indicate that histidine is an essential amino acid in normal and chronically uremic man. The absence of dietary histidine is associated with failure of normal erythropoiesis.

The Role of Histidine in the Anemia of Folate Deficiency:
The amino acid histidine is metabolized to glutamic acid in mammalian tissue. In normal subjects, histidine is excreted much more in the urine than other essential amino acids are. Hemoglobin protein contains 10% histidine. Under normal conditions, dietary histidine can supply sufficient histidine to prevent anemia. When the dietary intake is diminished or the urinary excretion is greatly increased, anemia results. It is concluded that folate deficiency causes histidine depletion through increased urinary excretion of this amino acid. Feeding histidine replenishes tissue levels of histidine, resulting in hemoglobin regeneration. Folic acid administration results in return of histidine to normal urinary levels. Thus, a combination of folic acid histidine would be beneficial for folate deficient individuals.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements. Do not use if you are at risk or are being treated for high blood pressure, liver, thyroid, psychiatric disease, diabetes or hypoglycemia. Do not use if you have had a myocardial infraction (heart attack). This supplement should be used by healthy adults only. Do not use unless you have obtained proper clearance from your healthcare professional. 

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