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Clinical Research on the effects of
CLA 1000 with Tonalin CLA
Studies show that CLA (the
active ingredient in Tonalin® CLA) works three ways to help you achieve your
diet goals.
1) CLA interferes with a substance in your body called lipoprotein lipase that
helps store fat in your body.
2) CLA helps your body use its existing fat for energy.
3) CLA increases lean muscle tissue, which
naturally slims your body (and makes you feel strong and healthy).
And the more muscle you have, the more calories your
body uses in order to function, thereby speeding up the fat burning process.
As a result, you get smaller in all the right places.
You drop clothes sizes. You look great.
You feel great. And no yo-yo dieting effect.
Dietary CLA has been shown to effect body composition by creating a reduction in
body fat and an enhancement of lean tissue or muscle. According to Michael
Pariza at the University of Wisconsin, this area of CLA research is the most
supported. Recently, the research has focused on
clinical studies with much success; showing
statistically significant reduction in body fat as measured by BMI
(Body Mass Index). A
significant decrease measured in waistline measured in inches, a
positive result for weight loss in mildly overweight subjects and an increase in
strength. Human clinical studies to substantiate improved body composition have
been conducted worldwide. Positive results of CLA supplementation have been seen
at research centers worldwide.
Kent State University, University of Memphis,
University of Wisconsin, USDA Western Human Research Center, Medstat Research
Ltd. in Norway, Uppsala University in Sweden, University of Kumanoto in Japan
and University of Tours in France.
CLA appears to exert direct effects on adipocytes, which are the principle sites
of fat storage and skeletal muscle cells and are the primary sites of fat
combustion. It has been proposed that the physiologic mechanism of body fat
reduction by CLA involves inhibition of fat storage in adipocytes coupled with
elevated b-oxidation in skeletal muscle. An overall increase in skeletal muscle
tissue may be mediated at least in part via the inhibition of immune-induced
catabolism.
CLA is a metabolically active compound that has been demonstrated to
dramatically reduce body fat and increase lean body tissue. The mechanisms of
action are not completely understood, but because CLA has been shown to affect a
wide variety of enzymes and hormones in the body, multiple mechanisms may come
into play. Numerous human studies are in progress, which will make a stronger
case for efficacy and dose response. Expectations are high that research will
additionally show no regain of body fat lost, suggesting that Tonalin™ CLA
should be included with every diet regimen.
Not only does Tonalin® have
no harmful side effects, but it's actually good for your body. As a matter of
fact, scientists worldwide are just beginning to understand CLA's wide range of
potential health benefits. Here are quick summaries of CLA's current four
principal health benefit areas.
CLA for
Cancer:
In the early 1980s, a noted
doctor, Michael Pariza, working at the University of Wisconsin and his
colleagues discovered that CLA interfered with the growth of cancer tumors.
Since then, a number of other studies have further shown CLA's cancer-fighting
potential. Some of these studies have shown that CLA can suppress cancer
development in animals, and in human cancer cell lines in vitro.
Dietary CLA also seems to protective against breast cancer in humans, as
demonstrated in a large French study by Lavillonniere et. al. at the University
Francois-Rabelais. When breast adipose tissue was collected at the time of
surgery, higher levels of CLA in the control group suggested CLA's protective
effect against breast cancer. A different study in Finland confirmed the reverse
correlation between milk fat intake, which contains CLA and breast cancer.
Over the next few years, additional studies are planned to help further
understand the role CLA may play in the fight against cancer.
Preventing
and Treating Artherosclerosis:
Over time, cholesterol and
other substances can form plaque in your arteries, narrowing them, reducing your
heart's blood supply. This is atherosclerosis, and it can kill you.
In a collaborative study where a diet high in cholesterol was fed along with CLA
to animals, the data suggested that CLA could help prevent atherosclerosis. By
week 12, the LDL and total cholesterol and triglyceride counts were markedly
lower in the blood of the animals fed CLA.
Other studies have indicated that CLA reduces plasma lipoproteins and early
aortic atherosclerosis in the animal model. According to Dr. David Kritchevsky
at the Wistar Institute, another significant finding is the apparent ability of
CLA to reduce the severity of preinduced atherosclerosis lesions in the animal
model.
Overall, CLA has considerable potential for the prevention and treatment of
atherosclerosis, and studies continue to reveal it's potential health benefits.
A Natural Ingredient for
Diabetics:
One of the most important
health benefits of CLA could possibly be its ability to affect and treat some
types of diabetes. According to Dr. Martha Belury at Purdue University and Dr.
John Vandel Heuvel at Penn State University, CLA normalizes impaired glucose
tolerance in non insulin-dependent diabetes. In earlier experiments by
Houseknecht et. al., it was observed that CLA and troglitazone reversed the
symptoms of diabetes in a specific diabetic animal model. Effects included
decreased triglycerides, insulin and leptin, and improved glucose utilization.
Belury and Vanden Heuvel conclude that CLA may represent an important agent for
the treatment of Type II diabetes.
Because CLA isomers share many of the attributes of the clinical
thiazolidinedione drug, troglitazone, without exhibiting as many side effects,
CLA may represent a new insulin-sensitizing agent for treatment of Type II
diabetes.
Additional clinical studies are scheduled at many universities worldwide in
order to further explore the possibilities of using CLA for diabetes treatment.
Strengthens Your Body’s
Defense Systems:
In
1991, evidence obtained through the collaborative efforts of Dr. Mark Cook and
Dr. Michael Pariza at the University of Wisconsin revealed the immune boosting
potential of CLA. Feeding CLA to chicks provided partial protection against the
catabolic effects of exposure to endotoxin. This research expanded to include
rodents and supported the fact that CLA-fed animals exhibit enhanced immune
functions.
CLA is the only known nutrient that enhances the immune system and protects
against the harmful "cellular backlash" that occurs when the immune system is
stimulated.
As published in separate issues of Cancer Research, CLA has been shown to be an
effective antioxidant in vitro according to Dr. Yeong Ha and in vivo according
to Dr. Clement Ip. Because numerous studies indicate that oxidative reactions
are associated with the development of cancer and atherosclerosis, CLA's ability
to reduce the harmful effects of these oxidative reactions could be its most
important health benefit
In addition, research suggests that CLA may ease the inflammation that occurs
when the immune system is challenged. |
