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Arginine Alpha-Ketoglutarate (AAKG 2:1)

99.98% pure pharmaceutical grade for maximum bioavailability.

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Boost Nitric Oxide to extend muscle pump, enhance muscle growth and get rock hard muscle: Arginine Alpha-Ketoglutarate (AAKG) can boost short term nitric oxide (NO) levels which creates a muscle growth environment in your body by increasing the volume of blood flowing through muscle tissue which leads to increased oxygen and nutrient delivery, glucose uptake, muscle velocity and power output. AAKG helps amplify muscle-growth signals giving faster gains in lean mass and accelerates both fast and slow twitch muscle fiber for greater strength, improved muscle recovery, and increased endurance. The increased blood flow may also contribute to enhanced sexual performance.

  • Supports protein synthesis.*
  • May increase levels Growth Hormone (GH).*
  • Increases nitric oxide to extend muscle pump.*
  • May Improve circulatory health and sexual function.*
  • Increases blood flow & nutrient delivery to muscle tissue.*

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Powder

NutraBio OU kosher Kosher
500 Grams Item #23240 $33.88 save 65%
1,000 Grams * Item #23241 $59.62 save 75%
2,500 Grams * Item #23242 $131.18 save 81%
700mg
Capsules
150 Caps Item #23246 $14.78 save 60%
500 Caps Item #23247 $39.96 save 68%
1,000 Caps * Item #23248 $66.50 save 75%
2,000 Caps * Item #23249 $117.44 save 83%
* Freshness Guarantee: To maintain product freshness we ship this product in multiples of 500 Gram or 500 Capsule bottles. For example if you order 1000 Grams you'll receive 2 bottles of 500 Grams each. Use the first bottle while the second stays sealed and fresh.

Powder is Kosher-pareve, Vegetarian, Hypoallergenic, Pharmaceutical. Gelatin caps are not kosher or vegetarian. No additives except a fractional amount of silica to prevent hardening.

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Arginine-AKG promotes increased nitric oxide (NO) production for enhanced blood flow and better delivery of oxygen and nutrients to working muscle. That means faster muscle growth & rock hard muscle.

Arginine Alpha-Ketoglutarate is for anyone who wishes to extend their muscle pump, signal muscle growth, speed recovery, increase their strength, stamina and sexual vigor. In addition, L–Arginine stimulates the production of Growth Hormone (GH), a chemical produced by the body that promotes growth and plays an essential role in metabolism. Growth Hormone (GH) is popular among athletes because it's believed to play a part in building lean muscle mass and increasing strength. Used in conjunction with your exercise program, AAKG may support myodilation, the expansion of muscle tissue. This product contains 100% Arginine-alpha-ketoglutarate in its purest form to give you continuous pumps and rock hard muscles.

Arginine-AKG is a more bio-available form of Arginine (or L–Arginine) which is a crystalline free-form amino acid involved in numerous areas of human biochemistry, including muscle metabolism, ammonia detoxification, hormone secretion and the immune system. L–Arginine is considered a semi-essential amino acid, because although it is normally synthesized in sufficient amounts by the body, supplementation is sometimes required. Arginine supports protein synthesis as it is involved in the transport and storage of nitrogen and is important for proper physical performance because it is used by the body to produce creatine.

L–Arginine is required for the synthesis of nitric oxide, a secondary messenger involved in blood flow. Nitric oxide is a compound that helps keep blood vessels dilated to promote healthy blood flow. Preliminary evidence suggests that arginine may be useful in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Arginine also stimulates protein synthesis and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illness. L–Arginine is beneficial for overall cardiovascular maintenance and sexual function as well as other areas that depend largely on healthy circulatory status.

An additional function and benefit of L-Arginine-AKG is its role as a precursor in creatine and glutamine production. Daily supplementation of L-Arginine-AKG has been shown to increase the body’s creatine and glutamine stores. This may lead to improvements in performance, strength and recovery for athletes.

Arginine Enhances Creatine Synthesis for greater muscle volumization:  L–Arginine was first isolated in 1886. In 1932, L–Arginine was found to be required for the generation of urea, which is necessary for the removal of toxic ammonia from the body. In 1939, L–Arginine was also shown to be required for the synthesis of creatine. Creatine degrades to creatinine at a constant rate, and is cleared from the body by the kidney. Arginine is also a precursor of guanido-phosphate, phosphor-arginine and creatine, the high-energy compounds found in muscles. L–Arginine has been used extensively by bodybuilders to increase blood flow to muscle tissue and to enhance creatine storage in the body although recently Arginine Alpha-ketoglutarate has become more popular. Arginine is also an important factor in muscle metabolism and works to transport, store and excrete nitrogen.

Alpha-Ketoglutarate Aminos are the Preferred Choice for Building Muscle:  Amino Acid Alpha-Ketoglutarates are amino acids with an alpha-ketoglutaric acid (AKG) molecule attached. This AKG transport molecule helps the amino acid bypass the gut and enter the muscle cell directly giving you superior absorption. Unlike L- form amino acids, AKGs are shuttled directly to the muscle cells rather than being absorbed and used by the small intestines for nucleotide synthesis. This makes AKG aminos the perfect choice if your goal is building muscle, but maybe not the best choice if you have more generalized health goals. AKG drives the amino acid into muscle cells creating a pro-muscle growth environment.

Amino acid alpha-ketoglutarates are technically amino acids derivatives. Their ergogenic effects are similar to those of their base free form amino acids, but by molecularly bonding it to AKG, its ergogenic effects become more pronounced within the muscle cell itself. The presence of the AKG molecule not only enhances the function of amino acid and overcomes its inherent limitations, but also increases its absorption rate thereby reducing the need for large doses, which may put less stress on the body. An added benefit is that AKG is a precursor to glutamine, so when the AKG is finished doing its job as a shuttle molecule it gets converted into glutamine. No waste - all benefit.

Warning - Fake AAKG has hit the Internet! NutraBio sells only the legitimate Arginine Alpha-ketoglutarate 2:1 which has been lab tested for potency and purity. Legitimate AAKG is a reacted compound where arginine is chemically bonded to alpha-ketoglutarate to form one single molecule. Don't be fooled by companies that blend arginine and alpha-ketoglutarate and call it AAKG, it's not – it’s a fake. For AAKG to be effective it must be a true reacted compound, not a blend. The cheap blended AAKG is not effective because the body treats the arginine and the alpha-ketoglutarate as two separate molecules so the alpha-ketoglutarate does not act as a shuttle to carry the arginine into the muscle cells. It’s useless. Unfortunately, the manufacturers of the raw material don’t even tell supplement companies that there is a difference, so many supplement companies don’t even know that they are selling an illegitimate product. Our onsite PHD chemist tests every single batch to insure that NutraBio AAKG is a legitimate chemically reacted product. This is one of the benefits of purchasing your supplements from an FDA registered and inspected GMP manufacturer, like NutraBio.

Beware of inferior AAKG 1:1 with 33% less arginine! There are 2 types of AAKG available on the market; a 2:1 ratio and a 1:1 ratio. We use only the 2:1 ratio which means that two molecules of arginine are chemically bonded to one molecule of alpha‎-‎ketoglutarate ‎(‎AKG‎). AAKG 2:1 is more effective because it contains 33% more arginine per serving than the 1:1 version. Remember, it's the arginine that gives you the muscle growth potential benefit within the muscle, while the AKG acts only as the shuttle system. A 3500 mg serving of AAKG 2:1 contains 2331 mg of active arginine as compared to only 1750 mg in the 1:1. Our AAKG 2:1 gives you 33% more arginine with no loss in bio-availability. Manufacturers use 1:1 because it's half the price and most customers never realize they’re getting ripped off.

Arginine Improves Growth Hormone (GH) levels:  Arginine stimulates the natural release of growth hormone and is a far safer and more cost effective alternative to growth hormone treatment such as HGH injections. Growth hormone is one of the most powerful hormones in the human body which promotes the growth of lean muscle tissue and the loss of fat. As you age, growth hormone levels drop, which is one reason you lose muscle and gain fat. In a controlled trial, when arginine and other amino acids were combined with weight training, a greater decrease in body fat was obtained after only five weeks than when the same exercise was combined with a placebo. Arginine is also needed to increase protein synthesis, which can in turn increase muscle growth. [1,2].

L–Arginine taken on an empty stomach can cause a significant release of growth hormone in many people. A dosage of between 10 and 30 grams of L–Arginine, depending upon factors such as age and body weight, is needed to have any impact on GH release. Taking arginine in capsule form is not recommended because it would take upwards of 20 capsules per serving to have a substantial impact on GH, which is why powder is the recommended delivery method. Growth hormone releasers should not be used by children until five years after they have completed their long bone growth (unless under careful medical supervision). The effectiveness of arginine for growth hormone release is age-dependent. A person in their twenties can get a very high release of growth hormone whereas a person in their fifties would get a lower response.

Growth Hormone (GH) for the athlete:  Athletes involved in intense exercise on a regular basis need Growth Hormone (GH) to increase energy, enhance lean body mass and to maintain strong bones and keep their weight under control. Availability of GH in systemic circulation also helps increase strength, burn fat, enhance libido, boost immunity and support tendons and ligaments. By inducing the secretion of GH from the pituitary, arginine and lysine stimulate muscle metabolism and, hence, provide nutritional support for the athlete. 

Which Arginine should I take to boost Growth Hormone (GH) and Nitric Oxide?  If you are taking arginine with the sole purpose of releasing growth hormone, the best alternative would be our Arginine Pyroglutamate Plus Lysine which is specifically designed and proven for this purpose and requires a much smaller dose of only 2.4 grams as opposed to 10 to 30 of L–Arginine. This smaller dose however will not be sufficient for nitric oxide release, nutrient delivery enhancement or sexual performance. If you are looking for both Growth Hormone and Nitric Oxide release than a good methodology would stacking multiple types of Arginine. Take 1-2 doses of Arginine Alpha Ketoglutarate (AAKG) earlier in the day and before workouts, and take one dose of Arginine Pyroglutamate and Lysine at night time. This stack gives you the most effective method for increasing nitric oxide to give you an ultimate muscle pump while improving GH levels for muscle growth. If taking two doses of AAKG or AEE earlier in the day make sure to separate both doses and the nighttime Arginine Pyroglutamate Plus Lysine by at least 3 hours. If you miss any of the doses, do not double up on the next dose just continue on with your next dose as normal.

Click here to view all arginine products.  

NutraBio.com Amino Therapy Amino Acids

We guarantee our supplements to be the freshest and purest: Our powders and capsules contain only pure active ingredient with absolutely no additives. Other manufacturers, in an effort to keep costs down, dilute their products with cheap fillers and add chemical excipients to their products to speed up their manufacturing output. These practices cheat you out of the active ingredient. At NutraBio, we've perfected our manufacturing technology so that excipients aren't needed, that means no microcrystalline cellulose, magnesium stearate, or other fillers, just pure active ingredient. NutraBio supplements are manufactured under the strictest standards producing the highest quality and purest supplements available anywhere. Our raw ingredients undergo state of the art HPLC analysis to insure zero tolerance for impurities.

Expiration 30 months minimum
Grade pharmaceutical
Purity 99.84%+ purity (HPLC)
Taste sour taste
Solubility good - mixes easy in water
Characteristics Hypoallergenic. Powder is vegan, vegetarian & kosher, the gelatin capsules are not.
Appearance off white powder
Odor none/slight
pH 6.5~7.0
Classification (Amino Acid): sports & muscle building, blood & nutrient delivery, Nitric Oxide, Growth Hormone, sexual enhancement.
CAS Registry 16856-18-1
Synonyms L–Arginine alpha-ketoglutarate,
L–Arginine 2-oxoglutarate,
Arginine alpha-ketoglutarate 2:1,
Arginine AKG, AAKG
Molecular Formula C6H14N4O2C5H6O5
Molecular structure

Manufactured from L–Arginine≈70%, AKG≈30%

Amino acids    Arginine & Arginine Derivatives 

Capsules

NutraBio - L-Arginine Alpha-Ketoglutarate - Supplement Facts (Capsules)

Suggested Use:

As a dietary supplement, take 2 servings daily on an empty stomach. On workout days, take one dose 15 minutes prior to your workout, take your second dose at least 4 hours before or after your first dose. On non-workout days time your doses at least 4 hours apart. To maximize results, drink at least 32 oz of water daily.

Powder

NutraBio - L-Arginine Alpha-Ketoglutarate - Supplement Facts (Powder)

Suggested Use:

As a dietary supplement, take 1 serving mixed into your favorite beverage twice daily on an empty stomach. On workout days, take 1 dose 15 minutes prior to your workout, take your second dose at least 4 hours before or after your first dose. On non-workout days, time your doses at least 4 hours apart. To maximize results, drink at least 64 oz. of water daily while using AAKG.


Vegetarian, Kosher & Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance. Our Arginine AKG powder is kosher and vegetarian, the gelatin capsules are not.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements. Do not use if you are at risk or are being treated for high blood pressure, liver, thyroid, psychiatric disease, diabetes or hypoglycemia. Do not use if you have had a myocardial infarction (heart attack). This supplement should be used by healthy adults only. Do not use unless you have obtained proper clearance from your healthcare professional.



NutraBio Pure
An unprecedented commitment to
quality, purity and freshness since 1996!

We manufacture in our own FDA registered and inspected GMP facility:

Since 1996, NutraBio has manufactured the purest pharmaceutical grade products available. We manufacture in the United States in our own FDA registered and inspected facility to meet FDA 21 CFR Part 111 cGMP regulations. All ingredients undergo state-of-the-art analysis to insure zero tolerance for impurities.

Truthful and Clear Supplement Facts Panels - No BS Proprietary Blends:

A proprietary blend is a cheap gimmick used by manufacturers to hide the real truth about what's in their product. By listing a bunch of ingredients under one blend on the label, the manufacturer only has to tell you how much of the blend is in a serving while hiding how much of each ingredient is in a serving. They pretend to this to protect their secret formula, that’s bull, they do it so they can cheapen their product without their customers knowing. In the industry we call this “Window Dressing” the product the label looks good on the outside but there is nothing really happening on the inside. At NutraBio our Supplement Facts panels list the exact amount of each and every active ingredient in the supplement. No guessing, you know exactly what you are getting in every product we sell.

Purchase manufacturer direct at wholesale price:

Buy directly from the manufacturer and save. We cut out the middlemen and pass the savings on to you. With NutraBio, you pay the same low wholesale price that the chain stores pay. Did you know that most companies do not manufacture their products but use 3rd party manufacturers? Since we manufacture all of our own products we can control the quality and purity through the entire manufacturing process. We never sell old or near expired products.

rev-20120124

1. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323, 1-6 .  2. Elam, R.P. (1988). Morphological changes in adult males from resistance exercise and amino acid supplementation. Journal of Sports Medicine and Physical Fitness, 28, 35-39 .  3. http://www.ncbi.nlm.nih.gov/pubmed/6790230?dopt=Abstract

 

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