Creatine Benefits Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease):

 

Creatine has proved so beneficial to patients with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's Disease, that the FDA has granted orphan drug status to creatine. The Avicena Group, Inc is sponsoring clinical trials on creatine and requested that the FDA approve creatine as an orphan drug.

 

Creatine, a natural substance, is critical for cellular energy production and modulation. It helps prolong the lives of cells and protects the cells from injury and death. This protective effect may be why creatine has been so beneficial in treating ALS, a progressive and fatal disease that disables motor neurons, the nerve cells that send signals from the brain to the skeletal muscles.

 

Researchers began conducting ongoing Phase II/III studies in 1999 at multiple centers coordinated by the Carolinas Neuromuscular ALS/MDA Center in Charlotte North Carolina and the North East ALS Consortium. The researchers are studying more than 300 patients at 29 sites. Preliminary data from these studies indicate creatine can indeed benefit ALS patients.

 

According to Dr. Jeffrey Rosenfeld, lead researcher of the Carolinas Neuromuscular ALS study, ALS patients treated with carnitine experienced increased muscle strength and decreased deterioration.

 

In addition to the above studies, Avicena has conducted numerous pre-clinical animal studies that show creatine, in mouse models, can prevent neurologic damage in ALS, Huntington's disease, and Parkinson's disease.

 

References:

(1) The Avicena Group literature

(2) Mazzini L, Balzarini C, Colombo R, Mora G, Pastore I, De Ambrogio R, Caligari M. Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. J Neurol Sci. 2001 Oct 15;191(1-2):139-44.

(3) Vielhaber S, Kaufmann J, Kanowski M, Sailer M, Feistner H, Tempelmann C, Elger CE, Heinze HJ, Kunz WS. Effect of creatine supplementation on metabolite levels in ALS motor cortices. Exp Neurol. 2001 Dec;172(2):377-82.

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